Anti-Desmin, clone 131-15014 (KN50-1-4)
| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| B, H , not Rb | IC, IH(P) | Mouse | Purified | Monoclonal Antibody |
UniProt Number:
UniProt Summary
FUNCTION: SwissProt: P17661 # Desmin are class-III intermediate filaments found in muscle cells. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures.
SIZE: 470 amino acids; 53536 Da
SUBUNIT: Homopolymer.
SUBCELLULAR LOCATION: Cytoplasm.
DISEASE: SwissProt: P17661 # Defects in DES are the cause of desmin-related cardio- skeletal myopat ... see more »
SIZE: 470 amino acids; 53536 Da
SUBUNIT: Homopolymer.
SUBCELLULAR LOCATION: Cytoplasm.
DISEASE: SwissProt: P17661 # Defects in DES are the cause of desmin-related cardio- skeletal myopat ... see more »
Entrez Gene Number:
Entrez Gene Summary
This gene encodes a muscle-specific class III intermediate filament. Homopolymers of this protein form a stable intracytoplasmic filamentous network connecting myofibrils to each other and to the plasma membrane. Mutations in this gene are associated with desmin-related myopathy, a familial cardiac and skeletal myopathy (CSM), and with distal myopathies.
Description:
Anti-Desmin, clone 131-15014 (KN50-1-4)
Clone:
131-15014 (KN50-1-4)
Trade Name:
Chemicon (Millipore)
Key Applications:
- Immunocytochemistry
- Immunohistochemistry (Paraffin)
Application Notes:
Immunocytochemistry: approximate concentration 40 µg/mL
Immunohistochemistry (frozen or de-paraffinized tissue): approximate concentration 40 µg/mL
Optimal dilutions must be determined by end user.
Immunohistochemistry (frozen or de-paraffinized tissue): approximate concentration 40 µg/mL
Optimal dilutions must be determined by end user.
Species Reactivity:
- Bovine
- Human
Non-Reactive Species:
Rabbit
Usage Statement:
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Antibody Sub-Category:
Cytoskeleton
Concentration:
1 mg/mL
Specificity:
Desmin
Antibody Category:
Cell Structure
Gene Symbol:
- DES
- CSM2
- FLJ41793
- FLJ41013
- FLJ39719
- CSM1
- FLJ12025
- Desmin.
- CMD1I
- desmin
Format:
Purified
Presentation:
Purified immunoglobulin. Liquid in 10 mM Phosphate buffer, 150 mM NaCl, pH 7.4, containing 0.1% sodium azide.
Isotype:
IgG1
Antibody Type:
Monoclonal Antibody
Storage Conditions:
Maintain at -20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles.
Host:
Mouse